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過氧化氫蒸汽 ( H P V ) 生物有效性

瀏覽次數:4993 發布日期:2017-6-23 

過氧化氫蒸汽 ( H P V ) 生物有效性

©Bioquell UK Ltd (2011). 版權所有                技術報告HPV 生物有效性069/11

過氧化氫蒸汽(HPV)滅菌的特點是無殘留(其分解產物只有水和氧氣)和僅需較低的環境溫度 ,蒸汽發生階段增加了滅菌過程的實用性。過氧化氫蒸汽(HPV)已經對許多生物及不同級別的生物進行了滅菌測試,實驗證明:過氧化氫蒸汽(HPV)對包括細菌、病毒和真菌在內的微生物均具有廣譜殺菌的功效。過氧化氫蒸汽(HPV)對于普遍存在于環境表面的細菌孢子滅殺的有效性經驗證是可以反復進行的,因此,它位于Spaulding分類中的第一位。文件中列出的有機體是按廣義分類的(例如細菌、病毒和真菌)并按照它們的微生物特點進行了劃分。實驗證明,利用過氧化氫蒸汽(HPV)對微生物進行消毒滅菌可達到6-log的滅殺率。

目錄

1 . 經測試的生物及參考文獻/出處

1.1 細菌和細菌孢子

1.2 病毒 

1.3 噬菌體 

1.4 真菌

1.5 線蟲類和原生動物

1.6 其他

2. 參考文獻/出處 

 1.  經測試的生物及參考文獻/ 出處

1.1 細菌和細菌孢子

1.2 病毒

1.3 噬菌體

1.4 真菌

1.5 線蟲類和原生動物

1.6 其他

i 證據顯示HPV可以滅活 蛋白質易傳染粒子 (38).

i 重要研究顯示HPV 對斷裂的DNA在分子生物學應用中起到至關重要的作用(39).

 

 2.  參考文獻/  出處

1. Rogers, J. V., C. L. Sabourin, Y. W. Choi, W. R. Richter, D. C. Rudnicki, K. B. Riggs, M. L. Taylor, and J. Ch a ng.

2005. Decontamination assessment of Bacillus anthracis, Bacillus subtilis, and Geobacillus stearothermophilus

spores on indoor surfaces using a hydrogen peroxide gas generator. J . Appl.Microbiol. 99:739-748.

2. Bacillus anthracis (Anthrax) deactivation investigation. Defence Science and Technology

Laboratory (Dstl), Porton Down UK. 2002.

3. Kokubo, M., T. Inoue, and J. Akers. 1998. Resistance of common environmental spores

of the genus Bacillus to vapor hydrogen peroxide. PDA.J.Pharm.Sci.Technol. 52:228 - 231.

4. McDonnell, G., G. Grignol, and K. Antloga. 2002. Vapour-phase hydrogen peroxide decontamination of

food contact surfaces. Dairy.Food.Environ.Sanitat. 22:868-873.

5. Spaulding, E. H. 1972. Chemical disinfection and antisepsis in the hospital. J.Hosp.Res. 9:5 - 31.

6. Rickloff, J. R. and reliski, P. A. 1989. Resistance of various micro-organisms to vaporized hydrogen peroxide in

prototype tabletop sterilizer. 89 th General Meeting of the American Society for Microbiology (ASM). New

Orleans.

7. Cabinet bio-decontamination trial. March 1995. Health Protection Agency (previously

Centre for Applied Microbiology and Research), Porton Down UK. 1995.

8. US Environmental Protection Agency (EPA) registered steril a nt. EPA registration number

72372-1 - 86703. 2009.

9. Johnston, M. D., S. Lawson, and J. A. Otter. 2005. Evaluation of hydrogen peroxide vapour as a method for the

decontamination of surfaces contaminated with Clostridium botulinum spores. J.Microbiol.Methods. 60:403 - 411.

10. Boyce, J. M., N. L. Havill, J. A. Otter, L. C. McDonald, N. M. Adams, T. Cooper,

A. Thompson, L. Wiggs, G. Killgore, A. Tauman, and J. Noble - Wang. 2008. Impact of hydrogen peroxide

vapor room decont a mination on Clostridium dif f icile environmental contamination and transmission in a

healthcare setting. Infect.Control.Hosp.Epidemiol.

29:723-729.

11. Otter, J. A. and G. L. French. 2009. Survival of nosocomial bacteria and spores on surfaces and inactivation

by hydrogen peroxide vapor. J.Clin.Microbiol. 47:205 - 207.

12. Case study f rom a room bio-decontamination at Imperial College School of Medicine.

2003. Contact Bioquell for further details.

13. Hall, L., J. A. Otter, J. Chewins, and N. L. Wengenack. 2007. Use of hydrogen peroxide vapor for deactivation of

Mycobacterium tuberculosis in a biological safety cabinet and a room. J.Clin.Microbiol. 45:810 - 815.

14. French, G. L., J. A. Otter, K. P. Shannon, N. M. Adams, D. Watling, a nd M. J. Parks.

2004. Tackling contamination of the hospital environment by methicillin-resistant Staphylococcus aureus

(MRSA): a comparison between conventional terminal cleaning and hydrogen peroxide vapour decontamination.

J.Hosp.Infect. 57:31-37.

15. Otter, J. A., M. Cummins, F. Ahmad, van Tonder C., and Y. J. Drabu. 2007. Assessing the biological ef f icacy and

rate of recontamin a tion following hydrogen peroxide vapour decontamination. J.Hosp.Infect. 67:182-188.

16. Jeanes, A., G. Rao, M. Osman, and P. Merrick. 2005. Eradication of persistent environmental MRSA.

J.Hosp.Infect. 61:85-86.

17. Dryden, M., R. Parnaby, S. Dailly, T. Lewis, K. Davis - Blues, J. A. Otter, and A. M. Kearns.

2008. Hydrogen peroxide vapour decontamination in the control of a polyclonal meticillin- resistant Staphylococcus

aureus outbreak on a surgical ward. J.Hosp.Infect. 68:190-192.

18. Determination of the effectiveness of VPHP against methicillin-resistant Staphylococcus aureus,

Staphylococcus epidermidis and Bacillus stearothermophilus. Health Protection Agency (previously Centre for

Applied Microbiology and Research),

Porton Down UK. 2001.

19. Assessment of the ef f icacy of vapour phase hydrogen peroxide as a room disinfectant. Health Protection Agency

(previously Centre for Applied Microbiology and Research), Porton Down UK. 2003.

20. Otter, J. A., S. Yezli, M. A. Shouten, A. R. van Zanten, G. Houmes - Zielman, and M. Nohlmans-Paulssen.

2010. Hydrogen peroxide vapor (HPV) decontamin a tion of an intensive care unit to remove

environmental reservoirs of multidrug-resist a nt

Gram - negative rods during an outbreak. Am.J.Infect.Control, accepted.

21. Bates, C. J. and R. Pearse. 2005. Use of hydrogen peroxide vapour for environmental control during a Serratia

outbreak in a neonatal intensive care unit. J.Hosp.Infect.

61:364-366.

22. Rogers, J. V., W. R. Richter, M. Q. Shaw, a nd Y. W. Choi. 2008. Vapour - phase hydrogen peroxide inactivates

Yersinia pestis dried on polymers, steel, and glass surfaces. Lett.Appl.Microbiol. 47:279-285.

23. Otter, J. A., J. Chewins, D. Windsor, and H. Windsor. 2008. Microbiological contamination

in cell culture: a potential role for hydrogen peroxide vapour (HPV)? Cell.Biol.Int.

32:326-327.

24. Rickloff, J. R. 1990. Use of Vapourized Hydrogen Peroxide for the Bio-decontamination of

Enclosed Areas. Interphex USA Con f erence. New York.

25. Heckert, R. A., M. Best, L. T. Jordan, G. C. Dulac, D. L. Eddington, and W. G. Sterritt.

1997. E f ficacy of vaporized hydrogen peroxide against exotic animal viruses.

Appl.Environ.Microbiol. 63:3916-3918.

26. Adenovirus deactivation trials. Conducted in commercial confidence. 2003. Contact Bioquell for

further details.

27. Viral deactivation trials. Conducted in commercial confidence. 2002. Contact Bioquell

for further details.

28. McDonnell, G., Belete, B., Fritz, C., and Hartling, J. 2001. Room decontamination with vapour hydrogen

peroxide VHP for environmental control of parvovirus. American Association for Laboratory Animal Science(AALAS), Annual meeting. Baltimore, MD.

29. Rudnick, S. N., J. J. McDevitt, M. W. First, and J. D. Spengler. 2009. Inactivating

influenza viruses on surfaces using hydrogen peroxide or triethylene glycol at low vapor concentrations.

Am.J.Infect.Control. 37:813-819.

30. Investigation into the efficacy of hydrogen peroxide vapour in the bio-deactivation of Dengue virus. 2003.

Conducted in commercial confidence. Contact Bioquell for f urther details.

31. Otter, J. A., M. Barnicoat, J. Down, D. Smyth, S. Yezli, and A. Jeanes. 2010. Hydrogen peroxide vapor (HPV)

decontamination of an intensive care unit room used to treat a patient with Lassa fever. J.Hosp.Infect.in press.

32. Otter, J. A. and A. Budde-Niekiel. 2009. Hydrogen peroxide vapor: a novel method for the environmental

control of lactococcal bacteriophages. J.Food.Prot. 72:412 - 414.

33. Pottage, T., C. Richardson, S. Parks, J. T. Walker, and A. M. Bennett. 2010. Evaluation of hydrogen peroxide

gaseous disinfection systems to decontaminate viruses.

J.Hosp.Infect. 74:55 - 61.

34. Information supplied with kind permission of Eli Lilly and Company, Indianapolis, Indiana.

1996.

35. Hall, L., J. A. Otter, J. Chewins, and N. L. Wengenack. 2008. Deactivation of the dimorphic f ungi

Histoplasma capsulatum, Blastomyces dermatitidis and Coccidioides immitis using hydrogen peroxide vapor.

Med.Mycol. 46:189-191.

36. Gustin, E. J., McDonnell, G. E., Mullen, G., and Gordon, B. E. 2002. The efficacy of vapour phase hydrogen

peroxide against nematode infestation: the Caenorhabditis ele g ans model. American Association for

Laboratory Animal Science (AALAS), Annual meeting. San Antonio, Texas, USA

37. Krause, J. and Riedesel, H. 2002. Elimination of pinworm eggs from caging equipment with vapourised

hydrogen peroxide. Report from the Max-Planck - Institute for experimental medicine. Association for

Laboratory Animal Science (AALAS) national meeting. San Antonio, Texas, USA

38. Fichet, G., K. Antloga, E. Comoy, J. P. Deslys, a nd G. McDonnell. 2007. Prion inactivation using a new gaseous

hydrogen peroxide sterilisation process. J.Hosp.Infect. 67:278 - 286.

39. DNA degradation studies. Conducted in commercial confidence. 2008. Contact Bioquell

for further details.

Bioquell公司的過氧化氫蒸汽(HPV)作為一種生物消毒劑因其對微生物具有廣譜殺菌及快速滅活的功效已在全球各國家/地區得到廣泛應用。

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