當(dāng)前位置 > 技術(shù)服務(wù) > 生物研發(fā)服務(wù)> 芯片與生物信息學(xué) > UNC3866研究進(jìn)展
|
UNC3866研究進(jìn)展
|
|||||||||||||||||
| [發(fā)表評論] [本類其他服務(wù)] [本類其他服務(wù)商] | ||||||||||||||||||
| 服務(wù)商： 上海皓元生物醫(yī)藥科技有限公司 | 查看該公司所有服務(wù) >> |
| <a href="https://www.medchemexpress.com/UNC3866.html">UNC3866</a>產(chǎn)品描述：UNC3866 is a potent antagonist of the <b>CBX7</b>-H3 interaction as determined by AlphaScreen (<b>IC<sub>50</sub></b>=66±1.2 nM) and is more than 100-fold selective for CBX7 over the other nine members of this methyl-lysine (Kme) reader panel. IC50 & Target: IC50: 66±1.2 nM (CBX7)<sup>[1]</sup> <i><b>In Vitro:</b></i> UNC3866, a potent antagonist of the methyl-lysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains. UNC3866 binds the chromodomains of CBX4 and CBX7 most potently with a K<sub>d</sub> of 100 nM for each, and is 6- to 18-fold selective versus seven other CBX and CDY chromodomains while being highly selective versus >250 other protein targets. UNC3866 inhibits PC3 cell proliferation, a known CBX7 phenotype, while UNC4219, a methylated negative control compound, has negligible effects. UNC3866 is a potent and cellularly active antagonist of PRC1 chromodomains. UNC3866 is the most potent ligand reported for CBX7 with a K<sub>d</sub> of 97±2.4 nM<br><br> <br> <span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商， 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個熱門研究領(lǐng)域，PI3K、MAPK等近千個細(xì)分靶點，超過4000個活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務(wù)。</span> <br style="color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height: 22.0px;background-color: rgb(251,251,251);"> <span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">MCE 對每批產(chǎn)品都進(jìn)行嚴(yán)格的LCMS和NMR檢驗，其產(chǎn)品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利；</span> <br style="color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height: 22.0px;background-color: rgb(251,251,251);"> <span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">MCE 定期增加各領(lǐng)域熱門抑制劑、激動劑，不斷擴(kuò)增已有化合物庫，以滿足最新的科研需求；</span> <br style="color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height: 22.0px;background-color: rgb(251,251,251);"> <span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">數(shù)千種產(chǎn)品在上海有充足備貨，24-48小時內(nèi)送達(dá)客戶；</span> <br style="color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height: 22.0px;background-color: rgb(251,251,251);"> <span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">大量產(chǎn)品提供免費試用裝；</span> <span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);"> 已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/unc3866.html">www.medchemexpress.cn/unc3866.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;" src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg" alt=""> |
手機(jī)版：UNC3866研究進(jìn)展
- BSI邀您參加蛋白質(zhì)組學(xué)數(shù)據(jù)分析培訓(xùn)會
- 單細(xì)胞空間多組學(xué)技術(shù)論壇暨廣州站生信培訓(xùn)班報名中
- SBC單細(xì)胞及空間多組學(xué)實驗與生信分析培訓(xùn)班招生
- 小海龜發(fā)布百個橫向課題、千篇SCI-生命科學(xué)合作計劃
- 空間多組學(xué)研究策略及生信分析培訓(xùn)班火熱招生中
- SBC ToolBox云平臺VIP專區(qū)再添新模塊GSEA數(shù)據(jù)分析
- SBC芯云講壇：國家自然科學(xué)基金的準(zhǔn)備和申報技巧
- 第十期SBC單細(xì)胞及空間轉(zhuǎn)錄組測序培訓(xùn)班報名通知
- 生物公共數(shù)據(jù)庫使用中的常見問題和解決方案
- ComplexHeatmap包繪制密度熱圖的參數(shù)調(diào)整和添加注釋方法
- DSP與LCM助力解析子癇前期蛻膜化抵抗機(jī)制
- GWAS全基因組關(guān)聯(lián)分析第一期：數(shù)據(jù)及格式轉(zhuǎn)換
- AI驅(qū)動精準(zhǔn)腫瘤學(xué)突破：MUSK模型助力醫(yī)學(xué)研究
- 在單細(xì)胞RNA測序中DoubletFinder雙細(xì)胞分析方法詳解
- scMega助力scATAC-seq數(shù)據(jù)與scRNA-seq數(shù)據(jù)的聯(lián)合分析
- 非負(fù)矩陣分解NMF算法助力單細(xì)胞轉(zhuǎn)錄組數(shù)據(jù)分析
更多
瀏覽該公司同類服務(wù)
瀏覽該公司同類服務(wù)
Copyright(C) 1998-2025 生物器材網(wǎng) 電話：021-64166852;13621656896 E-mail：info@bio-equip.com