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237 次 神經(jīng)系統(tǒng)中關(guān)鍵受體NK3R的功能作用及相關(guān)實(shí)驗(yàn)的介紹 2025-7-10
NK3R（速激肽受體3）是由TACR3基因編碼的一種蛋白質(zhì)。它屬于速激肽受體家族，是一種典型的G蛋白偶聯(lián)受體。NK3R發(fā)揮功能的關(guān)鍵在于結(jié)合其高親和力配體——神經(jīng)激肽B(NKB)。NK3R不僅參與
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214 次 壓力響應(yīng)型 miRNA - 5703 的過(guò)表達(dá)抑制壓力誘導(dǎo)的肝癌生長(zhǎng)和轉(zhuǎn)移 2025-7-9
Overexpression of pressure-responsive miRNA-5703 inhibits pressure-induced growth and metastasis of liver cancerKeywords: liver cancer; metastasis; miRNA-5703; portal hypertension;
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211 次 成纖維細(xì)胞中張力敏感的 HOX 基因表達(dá)用于差異瘢痕形成 2025-7-8
Tension-sensitive HOX gene expression in fibroblasts for differential scar formationKeywords: Scar formation, Hypertrophic scar; Keloid; Wound healing; Tension; Tension change; Ten
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277 次 C/EBPβ 拮抗劑誘導(dǎo)巨噬細(xì)胞促炎極化增強(qiáng)抗腫瘤免疫 2025-7-3
The C/EBPβ antagonist peptide lucicebtide (ST101) induces macrophage polarization toward a pro-inflammatory phenotype and enhances anti-tumor immune responsesKeywords: C/EBP&b
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323 次 小鼠主動(dòng)脈應(yīng)力激活平滑肌細(xì)胞適應(yīng)性程序維持強(qiáng)度防動(dòng)脈瘤和夾層 2025-6-30
Aortic Stress Activates an Adaptive Program in Thoracic Aortic Smooth Muscle Cells That Maintains Aortic Strength and Protects Against Aneurysm and Dissection in MiceKeywords: aort
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387 次 成骨細(xì)胞線粒體氧化應(yīng)激或自噬減少不足以模擬衰老對(duì)骨機(jī)械反應(yīng)性損害 2025-6-24
Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsivenessKeywords:
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229 次 苔蘚抑素-1（Bryostatin-1）通過(guò)抑制內(nèi)皮細(xì)胞自噬改善動(dòng)脈功能 2025-6-24
Bryostatin-1 improves function in arteries with suppressed endothelial cell autophagyKeywords: Aging; Bryostatin-1; Endothelial cell; Nitric oxide.內(nèi)皮功能障礙是心血管衰老的標(biāo)志，內(nèi)
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276 次 Piezo1 對(duì)抗與衰老相關(guān)的皮質(zhì)骨丟失 2025-6-24
Piezo1 opposes age-associated cortical bone lossKeywords: Piezo1; age-associated bone loss; endocortical bone resorption; mechanical stimulation.衰老會(huì)導(dǎo)致松質(zhì)骨和皮質(zhì)間隔的骨質(zhì)流失
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264 次 機(jī)械激活的間充質(zhì)衍生骨細(xì)胞通過(guò)細(xì)胞外囊泡介導(dǎo)的機(jī)制驅(qū)動(dòng)血管生成 2025-6-23
Mechanically activated mesenchymal-derived bone cells drive vessel formation via an extracellular vesicle mediated mechanismKeywords: Osteoblast; VEGF; angiogenesis; mechanobiology
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195 次 血管炎性疾病和內(nèi)皮表型 2025-6-17
Vascular Inflammatory Diseases and Endothelial PhenotypesKeywords: EC phenotypes; endothelial cell; inflammation; vascular diseases.內(nèi)皮細(xì)胞排列在管腔表面，充當(dāng)分隔血液和周?chē)M織的
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160 次 微管蛋白乙酰化增強(qiáng)機(jī)械應(yīng)力下小梁網(wǎng)細(xì)胞的微管穩(wěn)定性 2025-6-16
Tubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical StressKeywords: trabecular meshwork, glaucoma, tubulin acetylation, mechanical stre
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339 次 拉伸誘導(dǎo)的內(nèi)皮細(xì)胞單層損傷的相關(guān)研究 2025-6-10
Stretch-induced damage in endothelial monolayersKeywords: Aging; Cell mechanics; Endothelium; Mechanobiology; Senescence; Stretch.由于血流的脈動(dòng)性，包括流體剪切力、壓力和循環(huán)拉伸在
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377 次 視網(wǎng)膜神經(jīng)節(jié)細(xì)胞經(jīng)IL-12-SCGF-β串?dāng)_誘導(dǎo)干細(xì)胞衍生的神經(jīng)保護(hù)作用 2025-6-9
Retinal ganglion cells induce stem cell-derived neuroprotection via IL-12 to SCGF-β crosstalkKWS：Retinal ganglion cells；stem cell；neuroprotection；IL-12；SCGF-β；cross
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440 次 血管內(nèi)皮-間充質(zhì)串?dāng)_通過(guò) Notch 信號(hào)驅(qū)動(dòng)人成骨細(xì)胞的成骨分化 2025-6-4
Endothelial-mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through Notch signalingKeywords: Co-culture; Endothelial cells; Notch signaling; Osteoblast
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360 次 TRPV4 抑制劑和機(jī)械負(fù)荷對(duì)減輕炎癥的協(xié)同作用 2025-6-3
Synergetic role of TRPV4 inhibitor and mechanical loading on reducing inflammationKeywords: anti-inflammatory phenotype; inhibition, mechanical loading; macrophage polarization; mi
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406 次 I 類(lèi) PI3Ks 激活小梁網(wǎng)細(xì)胞中拉伸誘導(dǎo)的自噬 2025-5-27
Class I PI3Ks activate stretch-induced autophagy in trabecular meshwork cellsKeywords: Autophagy; Glaucoma; Mechanical stress; PI3K; Primary cilia; Trabecular meshwork.眼壓升高（IO
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332 次 內(nèi)皮 IGFBP6 抑制血管炎癥和動(dòng)脈粥樣硬化 2025-5-26
Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosisKWS：IGFBP6；vascular inflammation；atherosclerosis動(dòng)脈粥樣硬化通常發(fā)生在血流紊亂（DF）區(qū)域，例如動(dòng)脈分支或彎
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398 次 c-REL串?dāng)_TXNIP-p38與非經(jīng)典N(xiāo)F-κB通路協(xié)調(diào)紊亂血流區(qū)動(dòng)脈粥樣硬化 2025-5-20
Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathwaysKWS：c-REL, Shear stress, Endothe
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377 次 動(dòng)脈粥樣硬化中血流誘導(dǎo)的內(nèi)皮細(xì)胞重編程 2025-5-19
Flow-induced reprogramming of endothelial cells in atherosclerosisSubject terms: Cell biology, Systems biology動(dòng)脈粥樣硬化是一種主要影響動(dòng)脈的多因素慢性炎癥性疾病。內(nèi)皮細(xì)胞功能障礙
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404 次 E2F1誘導(dǎo)IL-6炎癥循環(huán)介導(dǎo)癌癥免疫，預(yù)測(cè)T細(xì)胞表型轉(zhuǎn)換和治療反應(yīng) 2025-5-13
E2F1-induced autocrine IL-6 inflammatory loop mediates cancer-immune crosstalk that predicts T cell phenotype switching and therapeutic responsivenessKeywords: CD4 +/CD8 + T cells;
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